Advances in Roles of Different Types of Histone Modifications in Responses of Rice to Abiotic Stresses

doi:10.16819/j.1001-7216.2025.250203

Abstract

Abstract:

As one of the most important food crops in the world, the yield and quality of rice are directly related to global food security. However, rice often faces various abiotic stresses during growth, such as salt stress, drought, low and high temperatures, which seriously compromise the growth, development and yield of rice. In recent years, epigenetics research, especially the role of histone modifications in regulating stress tolerance responses of rice, has attracted increasing attention. This review summarizes the latest research progress in histone modifications in abiotic stress responses in rice, to provide a theoretical basis for genetic improvement and stress resistance breeding of rice.

Key words: histone modifications, rice, abiotic stress

摘要：

水稻作为全球最重要的粮食作物之一，其产量和品质直接关系到全球粮食安全。然而，水稻在生长过程中常面临各种非生物胁迫，如盐胁迫、干旱、低温、高温等，严重影响水稻的生长发育和产量。近年来，表观遗传学研究尤其是组蛋白修饰在调控水稻耐胁迫响应中的作用日益受到关注。本文综述了组蛋白修饰在水稻非生物胁迫响应中的最新研究进展，以期为水稻遗传改良和抗逆育种提供理论依据。

关键词: 组蛋白修饰, 水稻, 非生物胁迫

HAO Wenqian, CAI Xingjing, YANG Haidong, WU Yuyang, TENG Xuan, XUE Chao, GONG Zhiyun. Advances in Roles of Different Types of Histone Modifications in Responses of Rice to Abiotic Stresses[J]. Chinese Journal OF Rice Science, 2025, 39(5): 575-585.

郝雯倩, 蔡兴菁, 杨海东, 吴宇阳, 滕轩, 薛超, 龚志云. 不同类型组蛋白修饰在水稻响应非生物胁迫中的研究进展[J]. 中国水稻科学, 2025, 39(5): 575-585.

Figures/Tables 2

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HMTs/HDMs家族 HMTs/HDMs Family		基因名称 Gene name	编号 Gene ID	功能分析 Functional analysis	组蛋白修饰位点 Histone modification site	参考文献 Reference
赖氨酸甲基化HKMTs	E(z)	SDG711	Os06g0275500	干旱胁迫；淀粉积累；光周期调控；穗发育	H3K27me3	[74]
赖氨酸甲基化HKMTs		SDG718	Os03g0307800	侧生器官发育	H3K27me3	[75]
	Ash	SDG724	Os09g0307800	光周期调控；	H3K36me2/3	[76]
		SDG708	Os04g0429100	开花调控；干旱胁迫	H3K36me2/3	[29]
		SDG725	Os02g0554000	开花调控	H3K36me3	[77]
		SDG723	Os09g0134500	干旱胁迫；开花调控；油菜素甾醇合成；穗发育	H3K4me3	[78]
	Trx	SDG721	Os01g0218800	盐胁迫；调控产量和株型	H3K4me3	[79]
		SDG705	Os01g0655300	细胞伸长；节间发育；赤霉素通路	H3K4me3	[80]
		SDG701	Os08g0180100	成花素基因表达；开花调控	H3K36me3	[81]
	ATXR5/6	SDG720	Os01g0965500	-	-
		SDG730	Os02g0122700	-	-
	Suv	SDG704	Os11g0602200	-	-
		SDG713	Os03g0320400	转座酶活性	H3K9	[82]
		SDG728	Os05g0490700	转座酶活性	H3K9me2	[82]
		SDG709	Os01g0811300	转座酶活性	H3K9	[83]
		SDG733	Os11g0131600	逆转录转座子的抑制	H3K9	[82]
		SDG734		转座酶活性	H3K9	[82]
		SDG714	Os01g0927000	毛状体形态发生调控；雌蕊发育	H3K9me2	[82]
		SDG726	Os07g0435900	-	H3K9	[82]
		SDG715	Os08g0565700	高温胁迫	H3K9me2	[84]
		SDG729	Os01g0811300	高盐敏感	H3K9	[83]
		SDG703	Os04g0544100	高温胁迫；灰飞虱抗性；雄配子减数分裂；分蘖数	H3K9me2	[82]
		SDG710	Os08g0400200	-	H3K9	[82]
		SDG712	Os02g0621100	开花调控	H3K9me2	[85]
	SMYD	SDG728	Os05g0490700	株高；雄配子减数分裂	H3K9me2	[82]
		SDG722	Os04g0629100	开花调控	H3K4me3，H3K36me3	[86]
精氨酸甲基化 PRMTs	PRMTs	OsPRMT1	Os09g0359800	根、茎、叶片、花和幼苗中都有表达，在成熟叶片中表达量高	H3R17, H4R3	[87]
		OsPRMT3	Os07g0640000	根、茎、叶片、花和幼苗中表达量都很低	H3, H4	[87]
		OsPRMT4	Os07g0671700	根、茎、叶片、花和幼苗中都有表达，在成熟叶片中表达量高	H3R17	[87]
		OsPRMT5	Os02g0139200	根、茎、叶、花和幼苗中的表达量均很低	H4R3	[87]
		OsPRMT6a	Os10g0489100	茉莉酸通路；小穗发育	H3, H4	[88]
		OsPRMT6b	Os04g0677066	根、茎、叶、花和幼苗中都有表达，表达量高于OsPRMT6a	H3R2, H3R17	[87]
		OsPRMT7	Os06g0105500	成熟叶片中表达稍高，根、茎、幼叶、花和幼苗中表达量很低	H3, H4	[87]
		OsPRMT10	Os06g0142800	根、茎、叶、花和幼苗中都有表达	H3R2, H4R3	[87]
赖氨酸去甲基化KDMs	LSD1	OsHDM701	-
赖氨酸去甲基化KDMs		OsHDM702	-
		OsHDM703	-
		OsHDM704	-
	KDM5/JARID1	JMJ703	Os05g0196500	高温胁迫；开花调控	H3K4me3	[89,90]
	KDM5/JARID1	JMJ704	Os05g0302300	开花调控	H3K4me2/3	[90]
		JMJ708	-	高温胁迫	H3K36me2	[89]
	KDM4/JHDM3	JMJ701	-
	KDM4/JHDM3	JMJ702	-
		JMJ705	Os01g0907400	-	H3K27me3
		JMJ706	Os10g0577600	-	H3K9me2/3
		JMJ707	-
	KDM3/JHDM2	JMJ715	-
	KDM3/JHDM2	JMJ716	-
		JMJ718	-
		JMJ719	-
		JMJ720	-
	JmjC domain-only	JMJ710		干旱胁迫	H3K36me2	[32]
		JMJ711		高温胁迫	H3K27me3
		JMJ712		高温胁迫	H3K27me3
		JMJ713		高温胁迫	H3K36me2	[89]
		JMJ714		-
		JMJ717		-
精氨酸去甲基化PADI4		-

HMTs/HDMs家族 HMTs/HDMs Family		基因名称 Gene name	编号 Gene ID	功能分析 Functional analysis	组蛋白修饰位点 Histone modification site	参考文献 Reference
赖氨酸甲基化HKMTs	E(z)	SDG711	Os06g0275500	干旱胁迫；淀粉积累；光周期调控；穗发育	H3K27me3	[74]
赖氨酸甲基化HKMTs		SDG718	Os03g0307800	侧生器官发育	H3K27me3	[75]
	Ash	SDG724	Os09g0307800	光周期调控；	H3K36me2/3	[76]
		SDG708	Os04g0429100	开花调控；干旱胁迫	H3K36me2/3	[29]
		SDG725	Os02g0554000	开花调控	H3K36me3	[77]
		SDG723	Os09g0134500	干旱胁迫；开花调控；油菜素甾醇合成；穗发育	H3K4me3	[78]
	Trx	SDG721	Os01g0218800	盐胁迫；调控产量和株型	H3K4me3	[79]
		SDG705	Os01g0655300	细胞伸长；节间发育；赤霉素通路	H3K4me3	[80]
		SDG701	Os08g0180100	成花素基因表达；开花调控	H3K36me3	[81]
	ATXR5/6	SDG720	Os01g0965500	-	-
		SDG730	Os02g0122700	-	-
	Suv	SDG704	Os11g0602200	-	-
		SDG713	Os03g0320400	转座酶活性	H3K9	[82]
		SDG728	Os05g0490700	转座酶活性	H3K9me2	[82]
		SDG709	Os01g0811300	转座酶活性	H3K9	[83]
		SDG733	Os11g0131600	逆转录转座子的抑制	H3K9	[82]
		SDG734		转座酶活性	H3K9	[82]
		SDG714	Os01g0927000	毛状体形态发生调控；雌蕊发育	H3K9me2	[82]
		SDG726	Os07g0435900	-	H3K9	[82]
		SDG715	Os08g0565700	高温胁迫	H3K9me2	[84]
		SDG729	Os01g0811300	高盐敏感	H3K9	[83]
		SDG703	Os04g0544100	高温胁迫；灰飞虱抗性；雄配子减数分裂；分蘖数	H3K9me2	[82]
		SDG710	Os08g0400200	-	H3K9	[82]
		SDG712	Os02g0621100	开花调控	H3K9me2	[85]
	SMYD	SDG728	Os05g0490700	株高；雄配子减数分裂	H3K9me2	[82]
		SDG722	Os04g0629100	开花调控	H3K4me3，H3K36me3	[86]
精氨酸甲基化 PRMTs	PRMTs	OsPRMT1	Os09g0359800	根、茎、叶片、花和幼苗中都有表达，在成熟叶片中表达量高	H3R17, H4R3	[87]
		OsPRMT3	Os07g0640000	根、茎、叶片、花和幼苗中表达量都很低	H3, H4	[87]
		OsPRMT4	Os07g0671700	根、茎、叶片、花和幼苗中都有表达，在成熟叶片中表达量高	H3R17	[87]
		OsPRMT5	Os02g0139200	根、茎、叶、花和幼苗中的表达量均很低	H4R3	[87]
		OsPRMT6a	Os10g0489100	茉莉酸通路；小穗发育	H3, H4	[88]
		OsPRMT6b	Os04g0677066	根、茎、叶、花和幼苗中都有表达，表达量高于OsPRMT6a	H3R2, H3R17	[87]
		OsPRMT7	Os06g0105500	成熟叶片中表达稍高，根、茎、幼叶、花和幼苗中表达量很低	H3, H4	[87]
		OsPRMT10	Os06g0142800	根、茎、叶、花和幼苗中都有表达	H3R2, H4R3	[87]
赖氨酸去甲基化KDMs	LSD1	OsHDM701	-
赖氨酸去甲基化KDMs		OsHDM702	-
		OsHDM703	-
		OsHDM704	-
	KDM5/JARID1	JMJ703	Os05g0196500	高温胁迫；开花调控	H3K4me3	[89,90]
	KDM5/JARID1	JMJ704	Os05g0302300	开花调控	H3K4me2/3	[90]
		JMJ708	-	高温胁迫	H3K36me2	[89]
	KDM4/JHDM3	JMJ701	-
	KDM4/JHDM3	JMJ702	-
		JMJ705	Os01g0907400	-	H3K27me3
		JMJ706	Os10g0577600	-	H3K9me2/3
		JMJ707	-
	KDM3/JHDM2	JMJ715	-
	KDM3/JHDM2	JMJ716	-
		JMJ718	-
		JMJ719	-
		JMJ720	-
	JmjC domain-only	JMJ710		干旱胁迫	H3K36me2	[32]
		JMJ711		高温胁迫	H3K27me3
		JMJ712		高温胁迫	H3K27me3
		JMJ713		高温胁迫	H3K36me2	[89]
		JMJ714		-
		JMJ717		-
精氨酸去甲基化PADI4		-

HAT/HDAC家族 HMTs/HDMs Family	基因名称 Gene name	编号 Gene ID	功能分析 Functional analysis	组蛋白修饰位点 Histone modification site	参考文献 Reference
p300/CBP	HAC701	Os01g14370	温度响应、高盐应激	H3K9ac, H4K12ac	[45,91,92]
	HAC703	Os02g04490	低温响应、高盐应激	H3K9ac, H4K12ac	[94]
	HAC704	Os06g49130	温度响应、高盐应激	H3K9ac, H4K12ac	[45,91,92]
GNAT	HAG702 (GCN5)	Os10g28040	高温响应	H3K9ac, H4K12ac	[94]
	HAG703	Os04g40840	高温响应、高盐应激; 干旱应激	H3K9ac, H4K12ac	[95]
	HAG704	Os09g17850	温度响应	H4K8ac	[91]
MYST	HAM701	Os07g43360	高盐应激、干旱应激	H3K9ac, H4K12ac	[93]
TAFII250	OsHAF701	Os06g43790	干旱应激	H3K9ac, H4K12ac	[91,93]
RPD3/HDA1	HDA701	Os01g40400	干旱应激	H3K9	[45,91,92,96]
	HDA702 (HDAC1)	Os06g38470	根生长	H3K14ac, H3K18ac	[97]
	HDA703 (HDAC3)	Os02g12350	干旱应激、病害应激	H4K8ac, H4K12ac	[52,98]
	HDA704	Os07g06980	干旱应激、剑叶形态	H4K8ac	[53]
	HDA705	Os08g25570	苗期渗透抗性、逆境激素应答、病害胁迫	H4K8ac	[47,96]
	HDA706 (HDAC6)	Os06g37420	高盐应激、根和叶的发育	H4K5ac, H4K8ac	[51]
	HDA707	Os01g12310	逆境激素应答		[99]
	HDA709	Os11g09370	干旱应激	H3K9ac	[100]
	HDA710 (HDAC2)	Os02g12380	高盐应激、干旱应激	H4K5ac, H4K16ac	[5]
	HDA711	Os04g33480	抑制叶片生长	H3K9ac	[100]
	HDA712	Os05g36920			[100]
	HDA713	Os07g41090		H3K9ac	[100]
	HDA714 (HDAC10)	Os12g08220	低温应答、高盐应答	H3K9ac	[100]
	HDA716	Os05g36930	种子萌发与生长	H3K9ac	[100]
HD-tuins	HDT701	Os05g51830	逆境激素应答、胁迫平衡	H3K9ac	[100]
	HDT702	Os01g68104	逆境激素应答、叶和茎的生长	H3K9ac	[100]
Sirtuin	SRT701	Os04g20270	低温应答、高盐应答	H3K9ac	[100]
	SRT702	Os12g07950	低温应答、高盐应答；干旱应激	H3K9ac	[101]

HAT/HDAC家族 HMTs/HDMs Family	基因名称 Gene name	编号 Gene ID	功能分析 Functional analysis	组蛋白修饰位点 Histone modification site	参考文献 Reference
p300/CBP	HAC701	Os01g14370	温度响应、高盐应激	H3K9ac, H4K12ac	[45,91,92]
	HAC703	Os02g04490	低温响应、高盐应激	H3K9ac, H4K12ac	[94]
	HAC704	Os06g49130	温度响应、高盐应激	H3K9ac, H4K12ac	[45,91,92]
GNAT	HAG702 (GCN5)	Os10g28040	高温响应	H3K9ac, H4K12ac	[94]
	HAG703	Os04g40840	高温响应、高盐应激; 干旱应激	H3K9ac, H4K12ac	[95]
	HAG704	Os09g17850	温度响应	H4K8ac	[91]
MYST	HAM701	Os07g43360	高盐应激、干旱应激	H3K9ac, H4K12ac	[93]
TAFII250	OsHAF701	Os06g43790	干旱应激	H3K9ac, H4K12ac	[91,93]
RPD3/HDA1	HDA701	Os01g40400	干旱应激	H3K9	[45,91,92,96]
	HDA702 (HDAC1)	Os06g38470	根生长	H3K14ac, H3K18ac	[97]
	HDA703 (HDAC3)	Os02g12350	干旱应激、病害应激	H4K8ac, H4K12ac	[52,98]
	HDA704	Os07g06980	干旱应激、剑叶形态	H4K8ac	[53]
	HDA705	Os08g25570	苗期渗透抗性、逆境激素应答、病害胁迫	H4K8ac	[47,96]
	HDA706 (HDAC6)	Os06g37420	高盐应激、根和叶的发育	H4K5ac, H4K8ac	[51]
	HDA707	Os01g12310	逆境激素应答		[99]
	HDA709	Os11g09370	干旱应激	H3K9ac	[100]
	HDA710 (HDAC2)	Os02g12380	高盐应激、干旱应激	H4K5ac, H4K16ac	[5]
	HDA711	Os04g33480	抑制叶片生长	H3K9ac	[100]
	HDA712	Os05g36920			[100]
	HDA713	Os07g41090		H3K9ac	[100]
	HDA714 (HDAC10)	Os12g08220	低温应答、高盐应答	H3K9ac	[100]
	HDA716	Os05g36930	种子萌发与生长	H3K9ac	[100]
HD-tuins	HDT701	Os05g51830	逆境激素应答、胁迫平衡	H3K9ac	[100]
	HDT702	Os01g68104	逆境激素应答、叶和茎的生长	H3K9ac	[100]
Sirtuin	SRT701	Os04g20270	低温应答、高盐应答	H3K9ac	[100]
	SRT702	Os12g07950	低温应答、高盐应答；干旱应激	H3K9ac	[101]