中国水稻科学

中国水稻科学

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转mtlD/gutD基因稻米对大鼠性腺毒性的实验研究

陈河1，2,王慧中2，*,赵文华1,蔡玲斐1,王灵均1,陈小囡1,黄大年3   

  1. 1杭州师范大学 医学院， 浙江 杭州310036； 2杭州师范大学 生物化学与分子生物学杭州市重点实验室， 浙江 杭州 310036； 3中国水稻研究所， 浙江 杭州 310006; *通讯联系人， E-mail:whz-2005@163.com
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2007-07-10 发布日期:2007-07-10

Study on Sexual Gland Toxicity of Transgenic Rice with mtlD/gutD Gene in Rats

CHEN He , WANG Hui-zhong , ZHAO Wen-hua , CAI Ling-fei , WANG Ling-jun , CHEN Xiao-nan , HUANG Da-nian
  

  • Received:1900-01-01 Revised:1900-01-01 Online:2007-07-10 Published:2007-07-10

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摘要： 研究了转mtlD/gutD双价基因稻米对大鼠的性腺毒性。通过对大鼠90 d喂养观察及对各组动物的睾丸和卵巢进行组织切片检查，未见有意义的病理改变。比较雌性大鼠的性成熟、雄性大鼠的精子畸变率及雌雄大鼠的性激素水平，各实验组与对照组均无显著差异(P＞0.05)。结果初步表明用转mtlD/gutD双价基因水稻秀水11品系T18781稻米喂养大鼠90 d对大鼠性腺器官的结构和功能无明显影响。

关键词: 转基因稻米, 大鼠, 性腺, 毒性, 性激素, 精子, 生物安全

Abstract: Sexual gland toxicity of transgenic rice with mtlD/gutD gene(rice line T18-7-8-1)in rats was studied.The results showed that no pathological changes were found in organs such as testis and ovary in rats in both experimental and control groups in a 90-day-feeding test by histological section examination.No significant differences(P>0.05)were observed on maturation of sexual gland in females,aberrant sperm rate of males and sexual hormone of rats between the experimental groups and the control.

Key words: transgenic rice, rat, sexual gland, toxicity, sexual hormone, sperm, biological safety